Vitamin D in kidney disease: pathophysiology and the utility of treatment.
نویسندگان
چکیده
CKD is associated with decreased vitamin D metabolites, both the storage form 25(OH)D and the active form 1,25-dihydroxyvitamin D. This contributes to hyperparathyroidism, and increased levels of PTH mobilize minerals from the skeleton and increase the risk for fractures. Treatment with vitamin D sterols efficiently reduces secondary hyperparathyroidism of CKD. Observational studies suggest survival and other potential benefits of vitamin D treatment in the CKD population. These observations need to be verified with controlled prospective trials.
منابع مشابه
P98: Vitamin-D Deficiency as a Potential Risk Factor in Multiple Sclerosis
Multiple sclerosis (MS) is a multifactorial disorder caused by the effects of several genes in combination with environmental factors. This disease is characterized by myelin loss, varying degrees of axonal pathology and inflammatory lesions. It is an important cause of disability in young adults, seen to be more prevalent in the woman, and affects 2.5 million people worldwide. Great efforts ar...
متن کاملComparison of serum vitamin D levels in elderly patients with and without Covid-19
Background and purpose: due to the occurrence of covid-19 disease in the world and the lack of standard treatment for this disease, a lot of research was done to find the causes of the disease and the methods of treatment. and is not infected with covid 19. Materials and methods: This study is a case-control study and its statistical population was elderly people who referred to Bandargaz city...
متن کاملVitamin D and the urgency of paying attention to this vital element in the body
Vitamin D is a vital element in the body that plays an important role in the growth and strength of muscles and bones by its effect on calcium absorption from the intestine. Vitamin D biosynthesis begins with the exposure to UV of sunlight from the skin. Cholecalciferol transfers from the skin and the intestine to the liver, and then binds to the DBP protein and eventually enters the kidney to...
متن کاملVitamin D deficiency in children with Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) and factors affecting response to cholecalciferol therapy: A quasi-experimental study from low-middle income setting
Background and Objective: Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) is characterized by hypocalcemia, hyperphosphatemia and abnormal vitamin D (VD) metabolism resulting in high parathyroid hormone secretion. The objective of the study was to determine VD status in children with CKD-MBD and the effect of cholecalciferol therapy in these children. Methods: This quasi-experimental st...
متن کاملVitamin D3 influence the Th1/Th2 ratio in C57BL/6 induced model of experimental autoimmune encephalomyelitis
Objective(s): Multiple Sclerosis (MS) is known as a progressive inflammatory CNS disease. Cytokines belong to Th1 or Th2 family and inflammatory cells, play significant role in pathophysiology of MS. Thus, any treatment supposed to influence the relation between Th1 to Th2 cytokines expression. Although vitamin D has been prescribed as a therapeutic supplement of MS for a long time, it is not c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Rheumatic diseases clinics of North America
دوره 38 1 شماره
صفحات -
تاریخ انتشار 2010